Effects of gabapentin, pregabalin and gastroretentive gabapentin on simulated driving, daytime sedation and cognition

Written by Peter Schmidt & Srinivas Rao

Analgesics prescribed to treat postherpetic neuralgia are known to cause sedation, but what are the effects of gabapentinoids gabapentin, pregabalin and gastroretentive gabapentin on sedation and cognitive function? Rao and Schmidt conducted a Phase I crossover study to investigate the relative impacts of these gabapentinoids on driving performance. The researchers also sought to characterize the effects of these three medications on cognition and subjective sedation and to examine correlations between these findings and plasma drug concentrations. Read the abstract below to find out more on this study, or read the full-text article in Pain Management here. Aim: Randomized Phase I...

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