Neurons prove difficult to excite in schizophrenia
Schizophrenia is associated with reduced synaptic gain, explaining hallmark electroencephalography signs.
Now, a study in Biological Psychiatry, led by Rick Adams (University College London, UK), has utilized electroencephalography (EEG) to determine that schizophrenia is associated with reduced synaptic gain (a loss of neural excitation), whilst hallucinations and other symptoms are associated with a loss of neural inhibition.