New key target identified in fight against glioblastoma

Written by Lauren Pulling

Researchers have identified a key protein essential for tumor formation in one of the deadliest forms of brain cancer, glioblastoma. Glioblastoma is resistant to chemotherapy and radiation therapy and is difficult to treat with surgery. The finding that the protein, termed Oncostatin M Receptor (OSMR), regulates tumor formation may help in the search for potential new treatments for the cancer. The study, published recently in Nature Neuroscience, is the first to identify the role of OSMR in glioblastoma. It reports that the protein is a cytokine coreceptor involved in the EGFRvII–STAT3 signaling pathway, which has previously been identified as crucial...

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