Novel antibodies highlight new cellular link in the development of amyotrophic lateral sclerosis

Written by Alice Weatherston

The discovery that mutations in the gene termed C9orf72 are the most common genetic cause of amyotrophic lateral sclerosis (ALS) in 2011 was a major breakthrough in the understanding of a disease that currently has no effective treatment options. Now, researchers from the University of Toronto (ON, Canada) have taken this research a step further and identified the key role of C9orf72 within diseased ALS neurons, using newly developed antibodies. The findings were published recently in Annals of Neurology. Janice Robertson and her team at the Tanz Centre for Research in Neurodegenerative Diseases (University of Toronto) were able to develop...

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