Researchers turn fibroblasts into neurons for Alzheimer’s disease model
Researchers have used microRNA-based direct reprogramming to generate neurons from fibroblasts, providing new insights into late-onset Alzheimer’s disease.
Aging is the most significant risk factor for Alzheimer’s disease and as populations age, the prevalence of Alzheimer’s continues to increase globally. Understanding the influence of aging on neurons and Alzheimer’s is crucial for developing new treatments; however, studies often rely on brain biopsies. Now, researchers from the Washington University School of Medicine in St. Louis (MO, USA) have developed a method for generating aged neurons in the lab from fibroblasts of individuals with late-onset Alzheimer’s.
