SfN17: CRISPR and iPSCs – new techniques to study the brain

Written by Martha Powell

Research presented at Society for Neuroscience’s annual meeting, Neuroscience 2017 (11–15 November 2017, Washington DC, USA), has highlighted advances in genetic and cellular techniques that may help to identify novel therapeutic targets for disorders including schizophrenia, Zika infection and addiction. One of the techniques explored was the gene-editing technology CRISPR-Cas9, which has been used by researchers to investigate the epigenetic mechanisms underlying cocaine addiction in mice. The progression of addiction has previously been closely linked with epigenetic mechanisms in the brain, and an understanding of these may accelerate the development of targeted therapies. In the study presented, the team repurposed...

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