Study addresses the debate around gender, genetics and Alzheimer’s disease

Written by Francesca Lake

When it comes to mutations in APOE, the long-standing yet controversial view is that women carriers of the ε4 allele are at a greater risk for late-onset Alzheimer’s disease (AD) than their male counterparts. However, a new meta-analysis has challenged this theory. Various studies have shown either that gender confers an increased risk, or none at all. The analysis saw researchers from the Keck School of Medicine at the University of Southern California, Los Angeles (CA, USA) analyze the relationship between gender , APOE genotype and risk of mild cognitive impairment (MCI) and AD using data covering nearly 58,000 patients...

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