TAF15: a vital proteomic clue to the mystery of frontotemporal dementia
Aggregates of TAF15 have been found in the brains of individuals with a type of early onset dementia, providing a new target for the treatment of this condition.
Researchers from the Medical Research Council Laboratory of Molecular Biology (Cambridge, UK) have identified the protein that forms aggregates in around 10% of individuals with a type of early onset dementia called frontotemporal dementia (FTD). The protein may also be implicated in motor neuron disease. This research could help develop new diagnostics and treatments for FTD.
