How chronic stress experienced during early development epigenetically programs adult disease risk

View webinar Q&A follow-up from James Coffman here Chronic psychosocial stress contributes significantly to the public health problems endemic to the modern world, many of which have also been linked to chronic inflammation. Epidemiological studies have shown that chronic stress experienced very early in life—even prenatally—increases the risk of developing inflammatory disease in adulthood, including mental health disorders such as anxiety and depression. Chronically elevated glucocorticoid (corticosteroid) signaling is one mechanism hypothesized to account for that correlation. Consistent with this, chronic exposure to elevated corticosteroids during early development has been found to have long term effects on adult behavior and...