Neurology Central

Alzheimer’s Research UK Conference 2018: Day 2

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Aging is inevitable but dementia is not. The Alzheimer’s Research UK (ARUK) manifesto, “the power to defeat dementia,” is not just a state motto, it is a goal. Through research, this mission can become a promising reality.
Read our conference report from Day 1 here

Energy metabolism, aging and neurodegeneration

The second and final day of the ARUK Conference 2018 (London, UK) was opened by Grahame Hardie from the University of Dundee (UK). Hardie presented a great talk on AMPK, its crucial role in regulating cell energy homeostasis and its potential target for drug treatment. The stage was then taken by Jill Fowler, ARUK Senior Research Fellow from the University of Edinburgh (UK). Fowler brilliantly illustrated how, following cerebral hypoperfusion, upregulation of the neuronal factor Nrf2 can prevent white matter damage and protect from cognitive impairment. This is even more interesting if one considers that cardiovascular conditions increase the likelihood of developing dementia. Helene Puln-Favreu from University College London (UCL; UK) closed the session with a beautiful talk on mitophagy in neurons and how targeting this cellular mechanism may be a possible therapeutic approach for neurodegenerative disease.

A coffee break and poster presentation followed the first session, which gave conference attendees and guest speakers not only the opportunity to exchange ideas but to observe the fascinating ongoing research through poster sessions and networking.

Insights from other dementias and diseases

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