Neurology Central

SfN 2018: Day 1 Update

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  • Davidson CJ, Naddaf MM, Holcomb DL, Bowen SE. Bing-like toluene exposure in periadolescence alters behavioral responsiveness to later ethanol and cocaine drug challenges in Swiss-Webster mice. In this study, researchers observed that when challenged with cocaine, PN36 toluene mice displayed less activity than controls at doses of 10 mg/kg and above, whereas PN44 toluene mice displayed less activity than controls at doses of 5 mg/kg. The data generated supports the hypothesis that early toluene exposure has the potential to significantly alter subsequent drug effects later in life.
  • Zelphati O, Di Scala C, Tessier M et al. A new polymer-based approach for in vivo transfection in postnatal brain. OZ Biosciences company, together with the INMED Institute of Neurobiology, developed a new delivery system named BrainFectIN, which allows for non-viral gene delivery of CNS cells. Using a brand new polyplexes-based approach in which DNA is complexed to BrainFectIN, the researchers demonstrated the potency to reach a large number of cells by applying a shRNA-encoding plasmid strategy. The team efficiently knocked down KCC2 in the hippocampus and thus modified brain activity significantly. Altogether, the researchers stated that BrainFectIN offers potent effect with reduced toxicity together with easy handling, opening new pathways for the next studies aiming at modifying cell populaitons within the CNS of postnatal animals.
  • Foster A, Wong KW, Murphy S, Pasternak T. Unilateral inactivation of lateral prefrontal cortex (LPFC) affects the retention of contralateral spatial and motor information during memory-guided comparisons. Investigators reported that LPFC inactivation resulted in deficits in remembering contralateral visual motion. At longer days, the monkey could not discriminate opposite directions of low coherence stimuli and lost precision with which the direction of coherent motion could be retained. Additionally, LPFC inactivation resulted in deficits in remembering contralateral spatial location. Exclusively contralateral deficits in remembering direction and its location highlights potential interactions between the LPFC and sensory neurons processing contralateral stimuli during sensory working memory tasks. To conclude, the researchers mention how these results document the contribution of the pre-arcuate region of the LPFC to short-term retention of both motion direction and its location, confirming physiological observations of its neurons carrying both types of signals. 

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Today at our booth

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