AICD linked to alzheimer’s pathology

Written by Alice Weatherston

New findings presented today at Neuroscience 2015 (17 – 21 October, Chicago, IL) have demonstrated that amyloid-beta Aβ may not be the only contributor to Alzheimer’s disease pathology. The study highlights the protein fragment, termed APP intracellular domain (AICD), as another potential cause of Alzheimer’s toxicity and damage, and indicates a new avenue for research into the disease. The research team based at CNRS (Valbonne, France) focused their investigation on the relatively little known amyloid precursor protein (APP) fragment AICD, which is formed in the same enzymatic process as Aβ. Despite its clear presence relatively little is understood about its...

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