Alzheimer’s disease may be prevented by experimental stroke drug

Researchers have discovered that 3K3A-APC, which is currently in development for treatment of ischemic stroke, may also prevent Alzheimer’s disease (AD). Berislav V Zlokovic from the University of Southern California (CA, USA) and a multidisciplinary team have reported that 3K3A-APC inhibits BACE1 amyloidogenic pathways in a mouse model of AD. The results were published in the Journal of Experimental Medicine. 3K3A-APC reduces inflammation and protects both neurons and the cells that line the walls of blood vessels from degeneration and death. The drug is currently in development as a neuroprotectant for the treatment of ischemic stroke and has been shown...