ßCTF implicated in the earliest stages of Alzheimer’s disease

Written by Emily Brown, Future Science Group

An early precursor of the amyloid beta (Aß) peptide – ßCTF – has recently been implicated in the early development of Alzheimer’s disease. A study carried out by investigators at the Nathan S. Kline Institute for Psychiatric Research and New York University Langone Medical Center (both NY, USA) has demonstrated the role of ßCTF in the earliest stages of the disease, where it is responsible for the initiation of a number of abnormalities that lead to the loss of neurons critical for memory formation. The findings appeared recently in Molecular Psychiatry. ßCTF is a protein formed during endocytosis – a...

To view this content, please register now for access

It's completely free