ßCTF implicated in the earliest stages of Alzheimer’s disease
A highly detailed 3D rendering of a double helix human DNA in blue color, with small carbon elements and light effects on a dark gray-blue background. The image shows an angle of view of different
An early precursor of the amyloid beta (Aß) peptide – ßCTF – has recently been implicated in the early development of Alzheimer's disease. A study carried out by investigators at the Nathan S. Kline Institute for Psychiatric Research and New York University Langone Medical Center (both NY, USA) has demonstrated the role of ßCTF in the earliest stages of the disease, where it is responsible for the initiation of a number of abnormalities that lead to the loss of neurons critical for memory formation. The findings appeared recently in Molecular Psychiatry. ßCTF is a protein formed during endocytosis – a...
