Alzheimer’s disease patient groups derived from a multivariate analysis of cognitive test outcomes in the Coalition Against Major Diseases dataset

Alzheimer’s disease (AD) is the most common form of dementia, accounting for 60–80% of all cases [1]. It is currently considered incurable and it eventually leads to death. The progression of this disease is mostly one-directional with the average survival times after diagnosis lying around 7 years [2], and the probability of living longer than 14 years is smaller than 3% [3]. The recognized main risk factors of AD comprise, but are not limited to, high age, mild cognitive impairment, lack of social engagement, low level of education, family history, APOE allele ε4 genotype, and cardiovascular disease and traumatic brain injury [1]. Although the...