Astrocytes derived from CD49f-induced stem cells can be toxic to neurons, study reveals

Written by Alice Bough, Future Science Group

A research group from The New York Stem Cell Foundation (NY, USA) has identified CD49f as a marker for human astrocytes. They then demonstrated that CD49f can be used to purify human induced pluripotent stem cell (hiPSC)-derived astrocytes, which could be made toxic to neurons. The results of the paper, published in Neuron, could provide insight into the function of human astrocytes in healthy and disease states. The group screened a range of neural cells to identify astrocyte-specific markers. They identified CD49f, a protein in the integrin alpha chain family, which had higher expression levels in astrocytes than in other...

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