Autoantibodies in neurological disorders – a review from Judith Greer

Written by Judith M Greer, The University of Queensland Centre for Clinical Research, Brisbane, Australia

Autoantibodies occur in many different nervous system disorders, and are increasingly being found in disorders not traditionally associated with the immune system. Determining if the autoantibodies play a functional or pathogenic role is critical in selecting the most appropriate treatment options. Association of autoantibodies with disorders of the nervous system Some diseases affecting the nervous system have a long history of association with autoantibodies. For example, the presence of oligoclonal bands of immunoglobulin in the cerebrospinal fluid (CSF) has been used for nearly 50 years in the diagnosis of multiple sclerosis (MS) [1], and the presence of antibodies that bind...

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