Body Mass Index and dementia, a conundrum

Written by Deborah R. Gustafson (University of New York—Downstate Medical Center, NY, USA & Sahlgrenska Academy at University of Gothenburg, Sweden)

The occurrence of overweight, obesity and Alzheimer’s disease (AD) are increasing in both developed and developing countries. The first study to report a risk association between AD and being more overweight or obese, measured via higher body mass index (BMI; kg/m2), was published in 2003 [1]. Since then the epidemiological literature on BMI and dementia has escalated and is somewhat mixed [2]. Before discussing the epidemiology however, one needs to understand both exposure and outcome. Exposure, Body Mass Index (BMI) A common and generally acceptable measure for underweight, overweight and obesity in the general population is body mass index (BMI),...

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