CYP2D6 and CYP2C19 genotyping in psychiatric patients on psychotropic medication in the former Dutch Antilles

Written by Anne B Koopmans, David J Vinkers, Petra JA Gelan, Hans W Hoek & Peter N van Harten

Aim: This study was aimed to asses the prevalence of CYP2D6 and CYP2C19 polymorphisms in psychiatric patients and in volunteers from Dutch caribbean origin. Methods: In total, 435 individuals were genotyped for CYP2D6 and CYP2C19. Of these, 269 were psychiatric patients on psychotropic medication, living in Curaçao and 166 were volunteers from the Dutch Caribbean population. Results: No differences in prevalence of alleles were found. Conclusion: Although prevalence of alleles appeared to be very different from African and Caucasian populations, the distribution into predicted phenotypes shows an equal distribution as in Caucasians. The CYPP450 is the most important pathway for the metabolization of lipophilic drugs into more hydrophilic compounds, which can be excreted by...

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