The ‘Dementia Preventative Initiative’: an individualistic approach to Alzheimer’s prevention

Written by Kelvin Adu-Darko

Neuroscientists at Florida Atlantic University (FL, USA) have been thinking ‘out-of-the-box’ by focusing on ways to prevent Alzheimer’s disease (AD). The program developed by James Galvin (Florida Atlantic University)and his colleagues is a 2-year clinical trial called the ‘Dementia Prevention Initiative’ (DPI). It has an unconventional ’N-of-1 design’, taking a personalized approach to studying and preventing dementia. “Because AD is heterogeneous in terms of risk factors, age of onset, presentation, progression, and pathology burden, designing a study to treat individuals as a homogenous population requires thousands of patients who have to be followed for years and even decades. This approach...

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