Pulse pressure could be a new therapeutic target for dementia

A group from The Brain Protection Company (Sydney, Australia) have proposed that elevated pulse pressure in blood traveling to the brain can promote cognitive decline and that it may even reduce the efficacy of treatments for dementia. The perspective article, published in Frontiers in Neuroscience, calls for academic and industrial researchers to develop treatment methods that can reduce pulse pressure. By making connections between the results of a large number of research papers, the group suggest that pulse pressure, which increases with age, can promote inflammation, oxidative stress and cellular damage in the blood–brain barrier. “Although there are likely several...