Disturbances in protein regulation offer new possibilities for schizophrenia treatment

Written by Courtney Johnson

Several studies involving scientists from Griffith University’s Eskitis Institute for Drug Discovery (QLD, Australia), the Royal College of Surgeons in Ireland (Dublin, Ireland) and University College Dublin (Ireland) have published findings that implicate dysregulated protein synthesis in the pathology of schizophrenia. The two studies, which both utilized adult stem cells of schizophrenia patients – comparing them with healthy control stem cells – observed increased protein levels but decreased rates of protein synthesis. The apparently contradictory results of the studies implicate the importance of disturbed protein regulation in the pathology of schizophrenia and indicate a cell-specific pathology for the disease. The...

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