First microarrayed 3D neuronal culture platform developed

Written by Sharon Salt, Editor

Credit: City University of Hong Kong – The new microarrayed 3D platform for performing the chemotactic experiments, enabling precise and systematic study on the neuronal sensitivity to the steepness of molecular gradient.

Neural development is often regulated by the graded distribution of guidance molecules, which are known to either attract or repel the neuronal migration or neurite projection when presented in concentration gradients (chemotaxis). However, the details behind these processes have been largely unexplored. In a recently published study in Nature Communications, a research team from City University of Hong Kong (CityU) has tried to tackle this by developing a new microfluidic platform for high-throughput generation of molecular gradients. It is well known that concentration gradients of guidance molecules, such as netrin or semaphoring (Sema) proteins, play critical roles in embryonic neural...

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