Influence of acylpeptide hydrolase polymorphisms on valproic acid level in Chinese epilepsy patients

21 Sep 2016

Written by Wen ZP, Fan SS, Du C et al.

Background: Concomitant use of meropenem (MEPM) can dramatically decrease valproic acid (VPA) plasma level. It is accepted that inhibition in acylpeptide hydrolase (APEH) activity by MEPM coadministration was the trigger of this drug–drug interaction. Aim: To investigate the influence of APEH genetic polymorphisms on VPA plasma concentration in Chinese epilepsy patients. Patients & methods: Urinary VPA-d6 β-D-glucuronide concentration was determined in 19 patients with VPA treatment alone (n = 10) or concomitant use with MEPM (n = 9). A retrospective study was performed on 149 epilepsy patients to investigate the influence of APEH polymorphisms rs3816877 and rs1131095 on adjusted plasma...