Novel gene therapy approach to Alzheimer’s

Written by Alice Weatherston

A new study has shown evidence of significant repair of synapse damage in mouse models of Alzheimer’s disease. The study, which focused on the delivery of APPsα to the brain, highlights potential new approaches to the development of novel gene therapies for Alzheimer’s. Results were published in Acta Neuropathologica recently. The research team concentrated on APP and its cleavage product APPsα, which has been highlighted as a potential protective agent against the neurotoxicity of beta amyloid peptides. “Research over the last few years indicates that a misregulation of the secretase cleavage in Alzheimer’s results in inadequate production of protective APPsα,”...

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