Nuclear receptor defects linked to autism spectrum disorders

Written by Sharon Salt

Two scientists from the University of Houston (TX, USA) have reported that defects in the dentate gyrus (DG) are regulated by a nuclear receptor – termed LXRβ – that may be linked to autism spectrum disorders (ASD). The DG is responsible for emotion and memory and is known to be involved in ASD. Margaret Warner and Jan-Åke Gustafsson (both from the University of Houston) have worked together for four decades in the discovery of nuclear receptors in brain functions. In 1996, Gustafsson was actually the scientist who first discovered LXRβ. Now in their present study, which was recently published in...

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