Sonogenetics – a new approach to manipulating neurons noninvasively

Written by Uri Magaram and Sreekanth H. Chalasani

As we continue to unravel the language of the brain, it becomes evident that precise firing patterns of different cell types in appropriate brain regions must work in concert to orchestrate the symphony of the mind.  Indeed, Francis Crick, several decades ago, predicted that one of neuroscience’s major hurdles would be learning to manipulate specific neurons in order to learn more about their function.  He was not wrong: the immense complexity of the brain makes it difficult to say with certainty that any observed neuronal physiology is causally linked to some observed phenotype; there are so many processes and so...

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