Spindle matrix proteins play an important role in neural stem cell reactivation

Written by Jonathan Wilkinson, Future Science Group

A research group from Duke-NUS Medical School (Singapore) have published findings reporting the intrinsic role of spindle matrix proteins in regulating neural stem cell (NSC) reactivation and proliferation. The findings, published in Nature Communications, could prove important in the development of stem cell-based therapies for neurodevelopmental and neurodegenerative disorders, including Alzheimer’s disease and microcephaly. The majority of NSCs within the brain remain in quiescence, with only a small number proliferative. The balance between these two states is integral for the development of the brain. It is thought that an imbalance between these two processes could be linked to neurodevelopmental disorders....

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