Tau filament formation can be inhibited with salbutamol, study reveals

A common asthma drug – known as salbutamol – may offer potential as a treatment option for Alzheimer’s disease, according to researchers at Lancaster University (UK). This new early-stage study has been published in ACS Chemical Neuroscience. The researchers used a novel tool called high-throughput synchrotron radiation circular dichroism (HT-SRCD) to study the structure of the misfolding tau protein. With this technique, the team were able to screen over 80 existing compounds and drugs simultaneously to determine their effectiveness at preventing the formation of tau fibrils. Epinephrine, which is more commonly referred to as adrenaline, was confirmed to be effective...