‘Punch drunk syndrome’: an early career perspective with Marc Goldfinger

Written by Sharon Salt (Editor)

Chronic traumatic encephalopathy (CTE), formerly known as dementia pugilistica or ‘punch drunk syndrome’, is described as a progressive neurodegenerative disease in people with a history of repetitive mild traumatic brain injury. The symptoms of CTE are extremely similar to those seen in other forms of dementia, particularly Alzheimer’s disease (e.g., cognitive impairment, memory loss, Parkinsonism, increasing confusion and disorientation, and slurred speech). As these clinical symptoms are shared with other neurodegenerative diseases, there’s currently no available test to diagnose the condition. At present, the most reliable way of confirming diagnosis of CTE is by examining post mortem brain tissue for certain changes. 

Click here to view Part 1 of the video.

To find out more, we spoke with Marc Goldfinger (Imperial College London, UK) about the disease. In Part 1 of the video, Marc provides us with a description of CTE, as well as a pathological demonstration illustrating the changes observed in post mortem brain tissues of individuals with CTE. He also talks us through his work with boxer’s brains, which focuses on a particular collection called the ‘Corsellis collection’. Click here to view it now. 

In this second part, Marc describes what his favorite aspect of his research has been so far, including further investigations he has planned. Marc also provides advice for early-career researchers looking to study CTE. 


00:10 – What has been your favorite aspect of research? 

01:38 – What further investigations do you have planned? 

03:25 – What advice would you give to early-career researchers? 

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