Original Publication Date: >21 September, 2017
Publication / Source: Biomarkers in Medicine
Authors: Ismail Thanseem, Vijitha Viswambharan, Suresh A Poovathinal et al.
Telomeres are DNA-protein complexes that form protective caps at the termini of chromosomes, maintaining genomic stability. In this review, we provide a comprehensive overview on the usefulness of telomere length (TL) as biomarkers of neurological disorders. The implications of TL in relation to cognitive ability, cognitive aging and cognitive decline in neurodegenerative disorders are also brieﬂy discussed. Our review suggests that at present it is difﬁcult to draw a reliable conclusion regarding the contribution of TL to neurological disorders. Further, it needs to be examined whether leukocyte TL, which is generally considered as a surrogate marker of TL in other tissues, serves as an indicator of central nervous system TLRestricted Content / Members Only
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