Authors: Sharon Salt, Editor
Researchers have discovered a vicious feedback loop underlying brain degeneration in Alzheimer’s disease, which may explain why so many drug trials have failed.
The study also identifies a clinically approved drug – fasudil – that could break the vicious cycle and protects against memory loss in animal models of Alzheimer’s.
Overproduction of the protein β-amyloid is strongly linked to development of Alzheimer’s disease but many drugs targeting β-amyloid have failed in clinical trials. β-amyloid attacks and destroys synapses and results in memory problems, dementia and ultimately death.