Neurology Central

SfN 2018: Day 4 Update


Video highlight

Today’s news

SfN18: Advances in brain–computer interfaces may improve therapies and prosthetics

Pick of the posters

  • Yokoi R, Matsuda N, Ishibashi Y, Odawara A, Suzuki I. Drug-induced seizure activities depending on the ratio of excitatory/inhibitory neurons in cultured human iPSC-derived neurons. This study aimed to examine the feature of spontaneous firings and the drug-induced seizure activities depending on the ratio of excitatory/inhibitory neurons in human iPSC-derived neurons. hiPSC-derived cortical neurons, in which the ratio of glutamatergic and GABAergic neurons are from 8:2 to 2:8 were cultured on MEA chips, and the spontaneous firings and pharmacological responses of convulsants were obtained by the 24-wells 384 ch MEA system (Presto). The researchers found that in drug-induced seizure activities, there was no remarkable dose responses in high percentage of excitatory neurons, and the network with high inhibitory neurons also showed significant activity changes in convulsants other than the inhibitors of GABA receptor. Additionally, the network with high inhibitory neurons also showed activity change at low concentrations. The investigators noted that these results suggest that a higher proportion of GABA neurons is more effective in detecting drug-induced seizure toxicity.
  • Zeng J, Sun F, Jing M et al. A genetically-encoded fluorescent sensor enables rapid and specific detection of dopamine in flies, fish and mice. This poster mentioned how norepinephrine and epinephrine are involved in many crucial physiological processes in diverse organs. However, the precise function and regulation of adrenergic and noradrenergic transmission in the majority of tissues remains poorly understood due partly to the limitations of the available techniques for monitoring their release. Here, the researchers developed a GRABne sensory, which responds to exogenous norepinephrine and epinephrine. They revealed that in vivo application of GRABne sensory in awake zebrafish and behaving mice unravel their capacity and robustness in specifically revealing endogenous norepinephrine dynamics. Thus, the researchers believe that GRABne sensor provides a new genetically encoded tool for dynamically monitoring adrenergic and noradrenergic transmission during physiological and pathological processes.
  • Robinson B, Gu Q, Dumas M, Kanungo J. Ketamine induces adverse effects on the development of monoaminergic neurons in zebrafish. A pediatric anesthetic, ketamine, has been implicated in cardiotoxicity and neurotoxicity including modulation of monoaminergic systems in mammals and zebrafish. In this study, the authors demonstrate ketamine’s effects on the development of monoaminergic neurons in the zebrafish embryos. Using whole-mount immunohistochemistry, they monitored the effects of ketamine on the brain serotonergic (5-HT) neurson and tyrosine hydroxylase-immunoreactive (TH-IR) neurons. They revealed that ketamine, at a dose that produces an internal embryo exposure level comparable to human anesthetic plasma concentrations, significantly reduced the areas occupied by 5-HT neurons in the brain of 48 hours post-fertilization embryos. In these embryos, TH-IR neurons in the brain and TH-IR cells in the trunk were also significantly reduced with ketamine treatment. These results indicate that longer exposure even with an anesthetic dose of ketamine can induce adverse effects on the development of both serotonergic and dopaminergic neurons.

Picture of the day

Meet the Neuro Central team – we’ve had so much fun at SfN this year and we even managed to squeeze in a cellfie!

Today at our booth

Today was the last day of SfN and unfortunately, our last day exhibiting at the conference. We can confirm after yesterday’s round-up that we did indeed surpass 1000 sign ups! If you haven’t already signed up with us, then you can still do so by clicking this link here. We can’t wait to see you all at next year’s conference in Chicago – don’t forget to keep checking back to our website for exciting announcements about any competitions we have coming up. We hope you all have safe travels home!

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