Ovarian cycle could modulate Alzheimer’s-related cognitive alterations in mice

Researchers at the University of California (CA, USA) have shown that ovarian stages considerably alter Alzheimer’s disease (AD)-related changes in neural network patterns and pathogenic protein production in a female mouse model of AD. The research paper was recently published in eNeuro. Lauren Broestl, lead author from the University of California, and colleauges found that female hAPP mice spent more time in estrogen-dominant cycle stages, causing cognitive impairments and worsened AD-related network dysfunction. However, progesterone-dominant stages and removal of the reproductive system reduced these AD-related problems. The researchers found that regardless of the similarities in cycle length and fertility, AD...