Cause of Alzheimer’s-related plaques linked to endocytic pathway abnormalities

Written by Lauren Pulling

Researchers from the University of California (UC; CA, USA) have demonstrated that protein abnormalities in the endocytic pathway may be linked to the axonal dysfunction and degeneration seen in Alzheimer’s disease (AD) and Down Syndrome (DS). AD and DS are characterized by amyloid plaques and neurofibrillary tangles; however, these manifestations are not detectable until the later stages of the disease. Some researchers believe that for successful treatment earlier disease characteristics must be targeted. Previous studies have highlighted dysfunction in the endocytic pathway as a precursor to AD, though the cause of this has not been identified. This new study, published...

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