Cause of Alzheimer’s-related plaques linked to endocytic pathway abnormalities
A highly detailed 3D rendering of a double helix human DNA in blue color, with small carbon elements and light effects on a dark gray-blue background. The image shows an angle of view of different
Researchers from the University of California (UC; CA, USA) have demonstrated that protein abnormalities in the endocytic pathway may be linked to the axonal dysfunction and degeneration seen in Alzheimer’s disease (AD) and Down Syndrome (DS). AD and DS are characterized by amyloid plaques and neurofibrillary tangles; however, these manifestations are not detectable until the later stages of the disease. Some researchers believe that for successful treatment earlier disease characteristics must be targeted. Previous studies have highlighted dysfunction in the endocytic pathway as a precursor to AD, though the cause of this has not been identified. This new study, published...
