Diapeutic cancer-targeting alkylphosphocholine analogs may advance management of brain malignancies

Written by Zhang RR, Swanson KI, Hall LT, Weichert JP, Kuo JS

The following is a special report on alkylphosphocholine analogs as targeted imaging and therapy agents for cancer, and their potential role in diagnosis and treatment in glioblastoma and brain metastases. These novel cancer-targeting agents display impressive tumor avidity with low background in the normal brain, and multimodal diagnostic imaging and therapy capabilities. The use of these agents may significantly improve diagnosis, treatment and post-treatment follow-up in patients with brain malignancies. ‘Theranostics’ are defined as diagnostic tests that inform treatment choice and clinical outcome. To improve patient outcomes, theranostics would ideally be used in therapy decision-making to predict treatment efficacy and...

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