Plasticity could make neurons more vulnerable to Alzheimer’s disease

A recent study has suggested that neurons that regularly remodel are more prone to Alzheimer’s disease (AD) and die when that remodeling goes wrong. The study, which has been published in Neuron, adds to work being conducted to track the progression of AD at the genetic and molecular levels within vulnerable neurons. Within the study, the investigators compared two types of neurons susceptible to AD with five resistant types by using a machine-learning framework that integrated neuron type-specific mouse experiments with human studies. From their findings, the most significant was that the vulnerable neurons were enriched with processes related to...