Targeting cerebrovascular impairments in Huntington’s disease: a novel treatment perspective

Written by Isabelle St-Amour, Benoit Aubé, Marie Rieux & Francesca Cicchetti

It is increasingly recognized that, in addition to blatant neuronal cell loss and the prominent expression of abnormal misfolded proteins, neurodegenerative disorders of the CNS are associated with significant alterations of the cerebral vasculature, in particular impairments of the neurovascular unit and increased permeability of the blood–brain barrier (BBB). Changes in brain-associated vascular networks are well characterized in Alzheimer’s disease (AD) and in normal aging [1]. However, they have received less attention in the context of other neurodegenerative conditions such as Huntington’s diseases (HD), despite the fact that the very first evidence of cerebrovascular-associated irregularities in individuals affected with HD...

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