Original Publication Date: >1 February, 2016
Publication / Source: Future Neurology
Authors: Rachelle Dugue & Frank C Barone
This review serves to link the role of the immune system in the neuropathology of acute ischemic stroke, traumatic brain injury and neurodegenerative disease. The blood–brain barrier delineates the CNS from the peripheral immune system. However, the blood–cerebrospinal fluid barrier acts as a gate between the periphery and the brain, permitting immune activity crosstalk and modulation.