Alzheimer’s disease ‘subtypes’ may be linked to different tau protein modifications

A recently published study in Nature Medicine has revealed that different ‘subtypes’ of Alzheimer’s disease could be linked to different forms of phosphorylated tau – a finding that may help explain why the disease has variable effects. It has long been known that, from person to person, substantial variations exist in the clinical presentation of Alzheimer’s disease (e.g., age of onset and rate of memory decline). In addition to this, levels of pathological tau in the brain have been linked to more severe disease, however, not much is known about what causes this variation. In this study, the researchers examined...