Blood–brain barrier dysfunction may be an early trigger of neurological aging in mice

Written by Sharon Salt, Editor

A recent set of studies have described how blood–brain barrier leakage can affect brain inflammation, leading to accelerated neurological aging in mice. The papers, which have been published in Science Translational Medicine, demonstrated that an experimental model of brain aging, where serum protein albumin was infused into the brains of rodents, could be ameliorated by blocking a signaling pathway in the brain. The research also revealed that a specific brain wave pattern, sometimes seen in individuals with Alzheimer’s disease, was also observed in rats who had albumin infused into their brains.   “When we infused albumin into the brains of young...

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