Brain tumor liquid biopsies are on the horizon

Written by Jade Parker, Future Science Group

In this study, researchers from the Cancer Research UK Cambridge Institute (UK) used whole-genome sequencing to analyze CSF from 13 glioma patients. By doing so, the team detected the copy number alterations in glioma using short cell-free DNA. The team detected tumor DNA in five (39%) of the patients. In one patient, multiple tissue samples from their brain tumor were compared with their CSF. The genetic changes broadly matched, but the CSF contained changes that were missed in some of the tissue samples, suggesting that CSF samples could reflect the repertoire of genetic alterations found in brain tumors. The findings...

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