Bumetanide could prevent prolonged convulsive seizures in epilepsy

A recent study published in Annals of Neurology has investigated the mechanisms underlying the formation of aberrant neural connections observed after an epileptic seizure. At the root of these findings is an abnormal depolarizing GABAergic drive, which studies suggest accelerates brain activity and leads to this incorrect re-wiring of connections in the brain. In this investigation, researchers at the University of Helsinki (Helsinki, Finland) studied rat epilepsy models to identify the relationship between GABA and the neural connections in the brain after a convulsive seizure. As Research Director Claudio Rivera (University of Helsinki) explained, GABA was found to accelerate depolarizing...