Elevating neuregulin 1 could alleviate Alzheimer’s symptoms

Written by Peter Brown

Researchers from the Salk Institute’s Clayton Foundation Laboratories for Peptide Biology (San Diego, CA, USA) have utilized rodent models to investigate the effects of increased hippocampal neuregulin 1 (NRG1) on Alzheimer’s disease (AD) symptoms and neuropathology. Utilizing a lentiviral vector system, the team demonstrated that elevated NRG1 may improve cognitive deficits and neuropathology in AD. Previous evidence has suggested that NRG1 signaling has the potential to influence cognitive function and neuropathology in AD, demonstrating the ability to reduce levels of amyloid precursor proteins. Additionally, conclusions from other studies have suggested that NRG1 has the potential to protect neurons from damage...

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