Is there a link between the sleep–wake cycle and Alzheimer’s pathology?

Written by Jee Hoon Roh & David M. Holtzman

Alzheimer’s disease (AD) has become a leading cause of morbidity and mortality and is even a greater cause of socio-economic burden as the average length of clinical disease spans more than 10 years [1]. While beneficial effects have been observed following administration of disease modifying treatments targeting amyloid-β (Aβ) in AD transgenic animal models, most clinical trials in human AD have not achieved such success [1]. The discrepancy between results in animal models versus what has been observed in humans may be related to the fact that there exists a longer period of preclinical AD in humans when the pathology...

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