Alzheimer’s tau structure revealed in first-of-its-kind study
Neurofibrillary tangles in pyramidal neurons of the human cerebral cortex a distinctive neuropathological feature of Alzheimer s disease AD detected through the silver carbonate method
Researchers at the Medical Research Council Laboratory of Molecular Biology (MRC LMB; Cambridge, UK), have presented the atomic structures of the abnormal tau filaments that are associated with Alzheimer’s disease (AD). In the first study of its kind, findings show cryo-electron microscopy maps and associated atomic models of paired helical and straight filaments taken from the brain of a patient with AD. The authors of the study – published this week in Nature – suggest that these findings could also demonstrate how tau protein may form different filaments in other neurodegenerative diseases. Tau was first identified as an integral component...
