New small-molecule drug may restore brain function in mouse model of Alzheimer’s disease

Written by Leigh Nugent

A new drug, termed anle138b, has been demonstrated to improve learning ability and restore normal brain activity in mice with an Alzheimer’s-like condition. The mice were previously displaying symptoms, including loss of memory, high levels of amyloid-beta and tau in the brain and abnormal brain function. Anle138b works by attaching itself to amyloid-beta and tau clusters, after which it deactivates the pores created by these clusters in the brain. This stops these pores from enabling the flow of toxic ions in and out of nerve cells, preventing neuronal dysfunction and cell death. Better still, the drug is easy to take....

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